Orchard Therapeutics, Ltd. (OTL) is looking for an experienced Scientist to develop and optimize lentiviral vector (LVVs) platform(s). This is a great opportunity to join the growing Process Development team within Cell & Gene Therapy Technologies department and contribute to the delivery of Orchard Therapeutics innovative gene-modified cell-based therapeutic products. The job role will include molecular biology, cell line development, process development, process characterization and manufacture of lentiviral vectors. The post-holder will also input into the transfer and implementation of optimized processes to GMP to support OTL's product pipeline programs.Key Elements and Responsibilities Develop stable cell lines for LVVs; Design, develop and improve process(es) (USP and DSP) for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development; Develop and perform cell-based and biochemical assays to characterise LVV processes and pro...
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